Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 6/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770757 | 0.92 | MEN1 (0.33) | MEN1KMT2APRKCAPRKCQLMNA | |
| SCHEMBL23770892 | 0.90 | RORC (0.35) | PRKCAPRKCQPTPN11EIF2AK4ACACB | |
| SCHEMBL23770853 | 0.88 | ABL1 (0.34) | MEN1KMT2ALMNARAB9AOPRM1 | |
| SCHEMBL23770829 | 0.88 | HDAC3 (0.33) | OPRM1PTPN11 | |
| SCHEMBL29464906 | 0.84 | KIF18A (0.33) | MEN1KMT2APRKCAPRKCQOPRM1 | |
| SCHEMBL19968854 | 0.84 | KIF18A (0.33) | MEN1KMT2APRKCAPRKCQOPRM1 | |
| SCHEMBL19970089 | 0.82 | BTK (0.36) | PRKCAPRKCQPTPN11EIF2AK4KIF18A | |
| SCHEMBL23770864 | 0.82 | HDAC3 (0.34) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL23770444 | 0.80 | ADRB2 (0.42) | — | |
| SCHEMBL23770508 | 0.79 | ABL1 (0.35) | MEN1KMT2AOPRM1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |