Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159035 | 0.88 | TBXAS1 (0.74) | TBXAS1TBXA2R | |
| SCHEMBL10470554 | 0.86 | TBXAS1 (0.75) | TBXAS1TBXA2R | |
| SCHEMBL7690245 | 0.85 | TBXAS1 (0.76) | TBXAS1TBXA2R | |
| SCHEMBL10471121 | 0.85 | TBXAS1 (0.76) | TBXAS1TBXA2R | |
| SCHEMBL20534073 | 0.84 | TBXAS1 (0.55) | TBXAS1TBXA2R | |
| SCHEMBL10470024 | 0.82 | TBXAS1 (0.58) | TBXAS1TBXA2R | |
| SCHEMBL9092744 | 0.82 | SIGMAR1 (0.53) | TBXAS1TBXA2RMTNR1AMTNR1B | |
| SCHEMBL5965847 | 0.81 | TBXAS1 (0.53) | TBXAS1TBXA2RMTNR1AMTNR1B | |
| SCHEMBL7502446 | 0.81 | TBXAS1 (0.53) | TBXAS1TBXA2R | |
| SCHEMBL1231801 | 0.80 | MTNR1A (0.55) | TBXAS1TBXA2RNR4A2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026280-B2 | For therapy of cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy. | ERRANT GENE THERAPEUTICS, LLC (US) | 2011-09-27 | — | — | US | claimed |
| EP-1590326-A4 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | LUNDBECK & CO AS H (DK) | 2008-04-30 | — | — | EP | disclosed |
| EP-1590326-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. Lundbeck A/S (DK) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004064764-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. LUNDBECK A/S (DK) | 2004-08-05 | — | — | WO | disclosed |
| US-4927838-A | CARDIOVASCULAR DISORDERS | HOFFMAN-LA ROCHE INC. (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0298466-A2 | Substituted alkene carboxylic acid amides and derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |