Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL302387 | 0.99 | OPRM1 (0.42) | OPRM1OPRL1MAPTCDK4CCND1 | |
| SCHEMBL2378645 | 0.91 | MEN1 (0.43) | OPRM1OPRL1MAPTCDK4CCND1 | |
| SCHEMBL2378536 | 0.91 | OPRL1 (0.49) | OPRM1OPRL1MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL302609 | 0.90 | MEN1 (0.43) | OPRM1OPRL1MAPTCDK4CCND1 | |
| Hydrochloric Acid SCHEMBL2382884 | 0.90 | OPRL1 (0.48) | OPRM1OPRL1MAPTKDM4EALDH1A1 | |
| SCHEMBL2378734 | 0.85 | MAPT (0.55) | OPRM1OPRL1MAPTCDK4CCND1 | |
| Hydrochloric Acid SCHEMBL303144 | 0.84 | MAPT (0.55) | OPRM1OPRL1MAPTCDK4CCND1 | |
| SCHEMBL2379177 | 0.82 | OPRL1 (0.47) | OPRM1OPRL1MAPTCDK4CCND1 | |
| Hydrochloric Acid SCHEMBL2378245 | 0.81 | OPRL1 (0.46) | OPRM1OPRL1MAPTCDK4CCND1 | |
| SCHEMBL3364830 | 0.81 | ALOX15 (0.56) | OPRM1OPRL1MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017630-B2 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2011-09-13 | — | — | US | claimed |
| EP-1751093-B1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2010-10-06 | — | — | EP | claimed |
| US-20070129347-A1 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | claimed |
| US-8017630-B2 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2011-09-13 | — | — | US | disclosed |
| EP-1751093-B1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2010-10-06 | — | — | EP | disclosed |
| US-20070129347-A1 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| EP-1751093-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005110976-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129347-A1 | Cyclohexylacetic acid compounds | ACACA, HCAR2, PCCA | OPRM1 3702/4885OPRL1 2478/4885MAPT 1493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.