SCHEMBL237865

SCHEMBL237865

C=C(C)C(=O)OC[Si](C)(OCCC)OCCC

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.49
THRB P10828 1/20 0.46
ALDH1A1 P00352 3/20 0.40
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
HTT P42858 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL666441 0.94 TSHR (0.44) TSHRTHRBALDH1A1
SCHEMBL5699018 0.90 TSHR (0.54) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL237187 0.86 TSHR (0.49) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL9757143 0.85 TSHR (0.50) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL143881 0.85 THRB (0.48) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL2246405 0.84 TSHR (0.51) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL229906 0.84 ALDH1A1 (0.42) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL235469 0.84 TSHR (0.50) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL1070990 0.81 TSHR (0.57) TSHRTHRBALDH1A1POLBAPEX1
SCHEMBL28240570 0.78 THRB (0.42) TSHRTHRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1298166-B1 RUBBER COMPOSITION JSR CORP (JP) 2007-02-21 EP claimed
US-6699935-B2 A CROSSLINKED RUBBER PARTICLES CONTAINING CONJUGATED DIENE MONOMER, AROMATIC VINYL MONOMER AND MONOMER WITH AT LEAST TWO POLYMERIZABLE UNSATURATED GROUPS DISPERSED IN A CONJUGATED DIENE/AROMATIC VINYL COPOLYMER; RESIST TO ROLLING, SKID, WEAR JSR CORPORATION (JP) 2004-03-02 US claimed
US-6653404-B2 Melt processability; dimensional stability JSR CORPORATION (JP) 2003-11-25 US claimed
US-20030125467-A1 A crosslinked rubber particles containing conjugated diene monomer, aromatic vinyl monomer and monomer with at least two polymerizable unsaturated groups dispersed in a conjugated diene/aromatic vinyl copolymer; resist to rolling, skid, wear JSR CORPORATION (JP) 2003-07-03 US claimed
EP-1298166-A1 RUBBER COMPOSITION JSR Corporation (JP) 2003-04-02 EP claimed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US claimed
EP-4349902-A1 RUBBER COMPOSITION AND TIRE BRIDGESTONE CORPORATION (JP) 2024-04-10 EP disclosed
US-11530318-B2 Rubber composition and pneumatic tire BRIDGESTONE CORPORATION (JP) 2022-12-20 US disclosed
WO-2022254751-A1 RUBBER COMPOSITION AND TIRE 株式会社ブリヂストン 2022-12-08 WO disclosed
EP-3851489-A1 MODIFIED MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, RESIN COMPOSITION, TIRE AND RESIN PRODUCT BRIDGESTONE CORPORATION (JP) 2021-07-21 EP disclosed
EP-3730547-A1 RUBBER COMPOSITION Bridgestone Corporation (JP) 2020-10-28 EP disclosed
EP-3725836-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Bridgestone Corporation (JP) 2020-10-21 EP disclosed
US-20200299489-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2020-09-24 US disclosed
US-20020045691-A1 Conjugated diene-based rubber, oil extended rubber and rubber composition containing the same JSR CORPORATION (JP) 2002-04-18 US disclosed
EP-1184415-A2 Conjugated diene-based rubber, oil extended rubber and rubber composition containing the same JSR Corporation (JP) 2002-03-06 EP disclosed
US-20020007011-A1 Crosslinked rubber particles and rubber compositions JSR CORPORATION (JP) 2002-01-17 US disclosed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US disclosed
EP-1152030-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-11-07 EP disclosed
EP-1149866-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-10-31 EP disclosed
EP-1149867-A2 Crosslinked rubber particles and rubber compositions JSR Corporation (JP) 2001-10-31 EP disclosed