SCHEMBL5699018

SCHEMBL5699018

C=C(C)C(=O)OC[Si](C)(OCCCC)OCCCC

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.54
THRB P10828 1/20 0.43
ALDH1A1 P00352 3/20 0.41
HPGD P15428 1/20 0.37
POLB P06746 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
APEX1 P27695 1/20 0.36
HTT P42858 1/20 0.36
ATM Q13315 1/20 0.35
HCAR2 Q8TDS4 1/20 0.32
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
NAAA Q02083 1/20 0.31
DGKA P23743 1/20 0.31
CES2 O00748 1/20 0.30
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9757143 0.95 TSHR (0.50) TSHRTHRBALDH1A1HPGDPOLB
SCHEMBL237865 0.90 TSHR (0.49) TSHRTHRBALDH1A1POLBTDP1
SCHEMBL2237451 0.85 TSHR (0.57) TSHRTHRBALDH1A1HPGDPOLB
SCHEMBL3503300 0.85 TSHR (0.56) TSHRTHRBALDH1A1HPGDPOLB
SCHEMBL140538 0.84 TSHR (0.60) TSHRTHRBALDH1A1HPGDPOLB
SCHEMBL666441 0.84 TSHR (0.44) TSHRTHRBALDH1A1
SCHEMBL10398150 0.83 TSHR (0.50) TSHRTHRBALDH1A1HPGDPOLB
SCHEMBL143881 0.82 THRB (0.48) TSHRTHRBALDH1A1POLBTDP1
SCHEMBL229906 0.81 ALDH1A1 (0.42) TSHRTHRBALDH1A1POLBTDP1
SCHEMBL7710883 0.80 TSHR (0.55) TSHRTHRBALDH1A1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036834-B1 ULTRAVIOLET-ABSORBING LAMINATED RESINOUS MATERIAL NIPPON CATALYTIC CHEM IND (JP) 2006-06-14 EP disclosed
US-6372355-B1 MINIMIZED COLORING OR DETERIORATION INDUCED BY ULTRAVIOLET RADIATION, WITH INTERLAYER ADHESION AND ABRASION RESISTANCE AND WEATHERABILITY NIPPON SHOKUBAI CO., LTD. (JP) 2002-04-16 US disclosed
EP-1036834-A1 ULTRAVIOLET-ABSORBING LAMINATED RESINOUS MATERIAL Nippon Shokubai Co., Ltd. (JP) 2000-09-20 EP disclosed
US-6037394-A ACRYLIC RESIN, BENZOTRIAZOLE, SOLVENT, AND ALKOXYSILANE REACTION PRODUCT WITH SILYLATION AGENT; PROTECTIVE COATINGS, WEAR RESISTANCE, WEATHERPROOFING SHIN-ETSU CHEMICAL CO., LTD. (JP) 2000-03-14 US disclosed
EP-0934987-A1 Primer composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-08-11 EP disclosed
US-5021266-A Silicon based protective coating SHIN-ETSU CHEMICAL CO., LTD. (JP) 1991-06-04 US disclosed