Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.84 |
| ▸ | MMP1 | P03956 | 12/20 | 0.84 |
| ▸ | MMP3 | P08254 | 11/20 | 0.84 |
| ▸ | MMP2 | P08253 | 6/20 | 0.84 |
| ▸ | MMP13 | P45452 | 6/20 | 0.84 |
| ▸ | MMP7 | P09237 | 1/20 | 0.84 |
| ▸ | MMP14 | P50281 | 1/20 | 0.84 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | RRM1 | P23921 | 1/20 | 0.31 |
| ▸ | RRM2 | P31350 | 1/20 | 0.31 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254495 | 1.00 | MMP9 (0.84) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL2379355 | 0.91 | MMP1 (1.00) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL4826862 | 0.91 | MMP1 (1.00) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL645121 | 0.91 | MMP1 (1.00) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL12247619 | 0.91 | MMP1 (1.00) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL12946005 | 0.91 | MMP1 (1.00) | MMP9MMP1MMP3MMP2MMP13 | |
| SCHEMBL12300383 | 0.90 | MMP1 (0.83) | MMP9MMP1MMP3MMP2MMP13 | |
| SCHEMBL6554365 | 0.89 | MMP2 (0.67) | MMP9MMP1MMP3MMP2MMP13 | |
| Rebimastat SCHEMBL12247617 | 0.89 | MMP1 (0.88) | MMP9MMP1MMP3MMP2MMP13 | |
| SCHEMBL1649754 | 0.89 | MMP3 (0.78) | MMP9MMP1MMP3MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390018-A1 | A PHARMACEUTICAL TABLET HAVING A HIGH API CONTENT | Bristol-Myers Squibb Company (US) | 2004-02-25 | — | — | EP | claimed |
| WO-2002087548-A1 | A PHARMACEUTICAL TABLET HAVING A HIGH API CONTENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-11-07 | — | — | WO | claimed |
| EP-1390011-A2 | CONTROL OF COMPACTABILITY THROUGH CRYSTALLIZATION | Bristol-Myers Squibb Company (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002088664-A2 | CONTROL OF COMPACTABILITY THROUGH CRYSTALLIZATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-11-07 | — | — | WO | disclosed |