Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201895 | 0.78 | — | — | |
| SCHEMBL6264890 | 0.77 | TSHR (0.32) | — | |
| SCHEMBL27627305 | 0.70 | TSHR (0.35) | FFAR1CPT2TDP1 | |
| SCHEMBL1132524 | 0.70 | ACLY (0.54) | TDP1 | |
| SCHEMBL4722124 | 0.69 | RIPK1 (0.34) | TDP1 | |
| Hydrochloric Acid SCHEMBL6275324 | 0.68 | ACLY (0.52) | TDP1 | |
| SCHEMBL16403157 | 0.67 | POLB (0.31) | — | |
| SCHEMBL1979249 | 0.67 | — | — | |
| SCHEMBL6275321 | 0.65 | ACLY (0.34) | FFAR1CPT2TDP1 | |
| SCHEMBL1027529 | 0.65 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | Method for Preparing a Spiroindoline | 2011-09-22 | — | — | US | disclosed |
| US-8022213-B2 | 6'-Bromo-1-[(5-methoxy-3-methyl-1H-indol-2-yl)carbonyl]-1'H-spiro[piperidine-4,4'-quinolin]-2'(3'H)-one; vasopressin receptors antagonist; antidepressant, anxiolytic agent; inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder | HOFFMANN-LA ROCHE INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-7723350-B2 | Spiroindolines as modulators of chemokine receptors | GLAXO GROUP LIMITED (GB) | 2010-05-25 | — | — | US | disclosed |
| US-20080318990-A1 | SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| US-20080161298-A1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161299-A1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-5977169-A | FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES | PHARMACIA & UPJOHN COMPANY | 1999-11-02 | — | — | US | disclosed |
| EP-0533243-B1 | Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0533244-B1 | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5693643-A | FOR PREVENTING PREMATAURE LABOR, STOPPING LABOR BEFORE A CESARIAN DELIVERY AND TREATING DYSMENORRHEA | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| WO-1995009631-A1 | SPIROVESAMICOLS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1995007901-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1995-03-23 | — | — | WO | disclosed |
| WO-1994014438-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO., INC. (US) | 1994-07-07 | — | — | WO | disclosed |
| US-5204349-A | Treatment of preterm labor, dysmenorrhea and for stoppage of labor prior to cesarian delivery | MERCK & CO., INC. (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0533244-A1 | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0533243-A1 | Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives | MERCK & CO. INC. (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0486280-A2 | Piperidinylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-5091387-A | Spirocyclic oxytocin antagonists | MERCK & CO., INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0450761-A1 | Spirocyclic oxytocin antagonists | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0444945-A2 | Use of spirocyclic compounds as oxytocin antagonists | MERCK & CO. INC. (US) | 1991-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318990-A1 | SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CCR10, CXCR2 | FFAR1 405/4885CPT2 2783/4885TDP1 4513/4885 |
| US-20080161299-A1 | SPIRO-PIPERIDINE DERIVATIVES | AVPR1A, AVPR1B, AVPR2 | FFAR1 467/4885CPT2 3729/4885TDP1 3475/4885 |
| US-20080161298-A1 | SPIRO-PIPERIDINE DERIVATIVES | AVPR1A, AVPR1B, AVPR2 | FFAR1 467/4885CPT2 3729/4885TDP1 3475/4885 |
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | CCR2, CXCR4, CXCR2 | FFAR1 228/4885CPT2 3541/4885TDP1 4282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.