Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19586225 | 0.72 | CRBN (1.00) | CRBNDDB1POLB | |
| SCHEMBL31704153 | 0.72 | CRBN (1.00) | CRBNDDB1POLB | |
| SCHEMBL31704110 | 0.72 | CRBN (1.00) | CRBNDDB1POLB | |
| SCHEMBL2107934 | 0.72 | CRBN (1.00) | CRBNDDB1POLB | |
| SCHEMBL22440147 | 0.71 | HSD11B1 (0.30) | — | |
| SCHEMBL31109516 | 0.71 | CRBN (0.67) | CRBNDDB1POLB | |
| SCHEMBL30851424 | 0.71 | CRBN (0.67) | CRBNDDB1POLB | |
| SCHEMBL9786755 | 0.71 | CRBN (0.67) | CRBNDDB1POLB | |
| SCHEMBL24832965 | 0.70 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL25480145 | 0.70 | CRBN (0.53) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180103-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-09-16 | — | — | WO | disclosed |