Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310569 | 0.86 | CYP2D6 (0.46) | HSD11B1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL2306003 | 0.85 | HSD11B1 (0.43) | HSD11B1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL2380691 | 0.84 | L3MBTL1 (0.46) | HSD11B1CYP2C19KMT2ACYP2C9L3MBTL1 | |
| SCHEMBL2379311 | 0.81 | OPRM1 (0.48) | TSHRLMNA | |
| SCHEMBL2381294 | 0.81 | L3MBTL1 (0.48) | HSD11B1CYP2C19CYP2C9L3MBTL1CYP3A4 | |
| SCHEMBL2309991 | 0.78 | ADRA1B (0.41) | HSD11B1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL2311285 | 0.78 | ALDH1A1 (0.44) | HSD11B1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL2310822 | 0.77 | HSD11B1 (0.44) | HSD11B1CYP2D6CYP2C19KMT2ACYP2C9 | |
| SCHEMBL2542785 | 0.74 | ALDH1A1 (0.57) | KMT2APOLBTSHRL3MBTL1LMNA | |
| SCHEMBL2305958 | 0.73 | CACNA2D1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815869-B2 | Lactam acetamides as calcium channel blockers | ABBVIE INC. (US) | 2014-08-26 | — | — | US | disclosed |
| WO-2011115813-A1 | LACTAM ACETAMIDES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-09-22 | — | — | WO | disclosed |
| US-20110230459-A1 | LACTAM ACETAMIDES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230459-A1 | LACTAM ACETAMIDES AS CALCIUM CHANNEL BLOCKERS | CACNA1E, CACNA1D, CACNA1S | SLC6A9 2836/4885HSD11B1 1413/4885CYP2D6 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.