Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23827362 | 1.00 | TDP1 (0.44) | TDP1TSHRMAPTLMNAPOLB | |
| SCHEMBL2731803 | 0.82 | LMNA (0.59) | LMNAL3MBTL1ADRB2ADRB1ADRB3 | |
| SCHEMBL8468149 | 0.82 | LMNA (0.59) | LMNAL3MBTL1ADRB2ADRB1ADRB3 | |
| SCHEMBL9283760 | 0.82 | LMNA (0.59) | LMNAL3MBTL1ADRB2ADRB1ADRB3 | |
| SCHEMBL5421055 | 0.82 | LMNA (0.59) | LMNAL3MBTL1ADRB2ADRB1ADRB3 | |
| SCHEMBL18990146 | 0.81 | LDHA (0.52) | TDP1TSHRMAPTLMNAPOLB | |
| SCHEMBL1548918 | 0.81 | PPARG (0.59) | RAB9ACYP1A2PPARGPPARAALDH1A1 | |
| SCHEMBL18990145 | 0.81 | LDHA (0.52) | TDP1TSHRMAPTLMNAPOLB | |
| SCHEMBL11451793 | 0.81 | NR4A2 (0.47) | TSHRMAPTLMNAPOLBNPSR1 | |
| SCHEMBL787523 | 0.80 | TDP1 (0.49) | TDP1TSHRMAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111171014-B | Monocyclolactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-112771040-B | Monocyclic lactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| US-20220002288-A1 | MONOBACTAM COMPOUNDS AND USE THEREFOR | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2022-01-06 | — | — | US | disclosed |
| EP-3882246-A1 | MONOBACTAM COMPOUNDS AND USE THEREFOR | Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) | 2021-09-22 | — | — | EP | disclosed |
| CN-112771040-A | Monocyclic lactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2021-05-07 | — | — | CN | disclosed |
| CN-111171014-A | Monocyclic lactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2020-05-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002288-A1 | MONOBACTAM COMPOUNDS AND USE THEREFOR | BPGM, IL1B, WEE1 | TDP1 3885/4885TSHR 4759/4885MAPT 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.