Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585247 | 0.87 | CRBN (0.49) | CES1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4585213 | 0.78 | ALDH1A1 (0.39) | CES1MAPTALDH1A1LMNA | |
| SCHEMBL1589486 | 0.75 | CES1 (0.57) | CASP3CES1MAPTALDH1A1TGM2 | |
| SCHEMBL29758482 | 0.75 | CES1 (0.57) | CASP3CES1MAPTALDH1A1TGM2 | |
| SCHEMBL9885117 | 0.73 | MAPT (0.40) | MAPTALDH1A1LMNA | |
| SCHEMBL12689505 | 0.72 | CASP3 (0.32) | CASP3CASP1CASP7CASP9CES1 | |
| SCHEMBL1854671 | 0.71 | ALDH1A1 (0.43) | IP6K1CASP1CASP7MAPTALDH1A1 | |
| SCHEMBL6283250 | 0.71 | CASP3 (0.57) | CASP3CASP1CASP7CASP9CES1 | |
| SCHEMBL22909290 | 0.69 | MAPK1 (0.50) | IP6K1MAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1085000 | 0.69 | CES1 (0.58) | CES1ALDH1A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230132973-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | THE UNIV OF BUEA (CM) | 2023-05-04 | — | — | US | disclosed |
| WO-2021186348-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-ISOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | THE UNIVERSITY OF BUEA (CM) | 2021-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132973-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | QDPR, NQO1, IDO2 | CASP3 278/4885IP6K1 276/4885CASP1 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.