Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 10/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23846329 | 0.87 | MAPT (0.50) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL23840604 | 0.78 | ITGA1 (0.45) | IDH1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL23833480 | 0.76 | GPR27 (0.48) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL30151063 | 0.76 | GPR27 (0.48) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL23840606 | 0.76 | ITGA1 (0.43) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL23840396 | 0.73 | PIK3CD (0.43) | IDH1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL23840609 | 0.73 | SMN1; SMN2 (0.40) | IDH1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL23833408 | 0.73 | MAPT (0.44) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL30151035 | 0.73 | MAPT (0.44) | IDH1ALPLMEN1MAPTKMT2A | |
| SCHEMBL23840608 | 0.73 | IDH1 (0.42) | IDH1ALPLMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188907-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |