Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA1 | P56199 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 10/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23840606 | 0.91 | ITGA1 (0.43) | ITGA1IDH1PGRALPLMEN1 | |
| SCHEMBL23833480 | 0.91 | GPR27 (0.48) | ITGA1IDH1ALPLMEN1KMT2A | |
| SCHEMBL30151063 | 0.91 | GPR27 (0.48) | ITGA1IDH1ALPLMEN1KMT2A | |
| SCHEMBL23833408 | 0.85 | MAPT (0.44) | ITGA1IDH1ALPLMEN1KMT2A | |
| SCHEMBL30151035 | 0.85 | MAPT (0.44) | ITGA1IDH1ALPLMEN1KMT2A | |
| SCHEMBL23840396 | 0.79 | PIK3CD (0.43) | IDH1ALPLMEN1KMT2AMAPT | |
| SCHEMBL23840609 | 0.79 | SMN1; SMN2 (0.40) | IDH1MEN1KMT2AMAPTGAA | |
| SCHEMBL23840316 | 0.78 | IDH1 (0.41) | ITGA1IDH1ALPLMEN1KMT2A | |
| SCHEMBL23840608 | 0.78 | IDH1 (0.42) | IDH1ALPLMEN1KMT2AMAPT | |
| SCHEMBL23840486 | 0.77 | IDH1 (0.40) | IDH1ALPLMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188907-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |