Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 10/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | SGK1 | O00141 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833385 | 0.90 | IDH1 (0.44) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL30151008 | 0.90 | IDH1 (0.44) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL23840604 | 0.79 | ITGA1 (0.45) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL25755146 | 0.79 | ALPL (0.54) | IDH1ALPLMAPTMEN1GAA | |
| SCHEMBL23840479 | 0.77 | CNR1 (0.42) | IDH1PIK3C3MAPTMEN1KMT2A | |
| SCHEMBL23840606 | 0.76 | ITGA1 (0.43) | IDH1PIK3C3ALPLMAPTMEN1 | |
| SCHEMBL23840609 | 0.76 | SMN1; SMN2 (0.40) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL23840608 | 0.75 | IDH1 (0.42) | IDH1PIK3C3ALPLMAPTMEN1 | |
| SCHEMBL23833363 | 0.75 | TUBB4A (0.50) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL30151018 | 0.75 | TUBB4A (0.50) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188907-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |