Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.40 |
| ▸ | ALPL | P05186 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30150995 | 0.91 | MAPT (0.46) | IDH1POLBGAAMAPTMEN1 | |
| SCHEMBL23833490 | 0.91 | MAPT (0.46) | IDH1POLBGAAMAPTMEN1 | |
| SCHEMBL23846447 | 0.88 | MAPT (0.46) | IDH1ALPLPOLBGAAMAPT | |
| SCHEMBL23840599 | 0.88 | PIK3C3 (0.36) | IDH1ALPLPOLBGAAMAPT | |
| SCHEMBL25758644 | 0.79 | LMNA (0.51) | IDH1ALPLPOLBGAAMAPT | |
| SCHEMBL30151060 | 0.78 | HTR2C (0.43) | POLBGAAMAPTMEN1KMT2A | |
| SCHEMBL23833429 | 0.78 | HTR2C (0.43) | POLBGAAMAPTMEN1KMT2A | |
| SCHEMBL23840606 | 0.78 | ITGA1 (0.43) | IDH1ALPLPOLBGAAMAPT | |
| SCHEMBL23840604 | 0.77 | ITGA1 (0.45) | IDH1ALPLGAAMAPTMEN1 | |
| SCHEMBL23840608 | 0.75 | IDH1 (0.42) | IDH1ALPLMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188907-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |