Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | IDH1 | O75874 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23846447 | 0.91 | MAPT (0.46) | LMNASMN1; SMN2MAPTGAAPOLB | |
| SCHEMBL30150995 | 0.88 | MAPT (0.46) | LMNASMN1; SMN2MAPTGAAPOLB | |
| SCHEMBL23833490 | 0.88 | MAPT (0.46) | LMNASMN1; SMN2MAPTGAAPOLB | |
| SCHEMBL25754534 | 0.88 | MEN1 (0.49) | LMNASMN1; SMN2MAPTGAAPOLB | |
| SCHEMBL23840486 | 0.79 | IDH1 (0.40) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL23833429 | 0.75 | HTR2C (0.43) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL30151060 | 0.75 | HTR2C (0.43) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL25757369 | 0.75 | LMNA (0.54) | LMNASMN1; SMN2MAPTGAAPOLB | |
| SCHEMBL25758942 | 0.75 | LMNA (0.59) | LMNASMN1; SMN2MAPTGAAMEN1 | |
| SCHEMBL30199798 | 0.74 | LMNA (0.53) | LMNASMN1; SMN2MAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | LMNA 3435/4885SMN1; SMN2 405/4885MAPT 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.