Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13153124 | 0.80 | KMT2A (0.46) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL31706376 | 0.80 | CHEK1 (0.45) | CHEK1IDO1TDO2RETPI4KA | |
| SCHEMBL19966396 | 0.77 | FGFR1 (0.39) | CHEK1IDO1RETPI4KAXDH | |
| SCHEMBL24348557 | 0.77 | PLK4 (0.38) | CHEK1IDO1RETPI4KAXDH | |
| SCHEMBL30509508 | 0.77 | ALDH1A1 (0.40) | IDO1TDO2PDPK1PLK4PAK4 | |
| SCHEMBL25322760 | 0.77 | ALDH1A1 (0.40) | IDO1TDO2PDPK1PLK4PAK4 | |
| SCHEMBL26661515 | 0.76 | TRPA1 (0.39) | CHEK1IDO1RETPI4KAXDH | |
| SCHEMBL2817605 | 0.75 | ADORA2A (0.45) | LRRK2MAPTMEN1KMT2AADORA2A | |
| SCHEMBL18012909 | 0.73 | BACE1 (0.43) | CHEK1RETPI4KAXDHLRRK2 | |
| SCHEMBL20656567 | 0.73 | ALDH1A1 (0.39) | CHEK1IDO1PDPK1PLK4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188871-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-09-23 | — | — | WO | disclosed |