Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10597939 | 0.78 | PNP (0.33) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20866 | 0.78 | ATAD2 (0.41) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL218666 | 0.76 | GDA (0.34) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2385672 | 0.76 | PNP (0.44) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8886026 | 0.76 | PNP (0.35) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3259641 | 0.76 | PNP (0.35) | PNPPDE4APDE4BPDE4CPDE4D | |
| Sulfuric Acid SCHEMBL9697700 | 0.75 | PNP (0.30) | PNP | |
| Bromide SCHEMBL8165610 | 0.75 | GDA (0.33) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2051359 | 0.74 | PNP (0.34) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1843775 | 0.74 | PNP (0.34) | PNPPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552947-A2 | VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF | Trustees of Dartmouth College (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120013-A2 | VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2005046661-A2 | USE OF NITRIC OXIDE DONORS FOR THE TREATMENT OF DRUG ADDICTION | UNIVERSITY OF SHEFFIELD (GB) | 2005-05-26 | — | — | WO | disclosed |
| EP-1450861-A2 | TARGETING NUCLEIC ACIDS TO A CELLULAR NUCLEUS | Mirus Corporation (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003012039-A2 | TARGETING NUCLEIC ACIDS TO A CELLULAR NUCLEUS | MIRUS CORPORATION (US) | 2003-02-13 | — | — | WO | disclosed |