Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SI | P14410 | 2/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408540 | 0.73 | TSHR (0.46) | TSHRHSD17B10KDM4ELMNANPC1 | |
| SCHEMBL17767164 | 0.73 | GPR139 (0.64) | GPR139TSHRHSD17B10NPSR1 | |
| SCHEMBL1689837 | 0.72 | GAA (0.67) | HSD17B10MGAMAMY1AGAASI | |
| SCHEMBL38666254 | 0.72 | KEAP1 (0.46) | HSD17B10KDM4EMGAMAMY1AGAA | |
| SCHEMBL23361234 | 0.71 | NPC1 (0.43) | GPR139LMNANPC1RAB9APTK2 | |
| SCHEMBL11983636 | 0.69 | ALDH1A1 (0.68) | GPR139HSD17B10GAANPC1RAB9A | |
| SCHEMBL13963730 | 0.69 | FAAH (0.45) | HSD17B10KDM4ELMNAMGAMAMY1A | |
| SCHEMBL17767225 | 0.64 | GPR139 (0.64) | GPR139TSHRHSD17B10NPSR1 | |
| SCHEMBL13032599 | 0.62 | CYP3A4 (0.50) | HSD17B10KDM4ELMNAALDH1A1MAPT | |
| SCHEMBL202954 | 0.62 | KMO (0.63) | GPR139MGAMAMY1AGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885352-A1 | A COMPOUND, COMPOSITIONS THEREOF AND THIS COMPOUND FOR USE IN METHODS OF TREATING CNS DISORDERS | Sage Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |