SCHEMBL2386648

SCHEMBL2386648

O=C(c1ccccc1)c1ccc(OCC(=O)N(CCO)CCO)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.64
GAA P10253 1/20 0.60
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
ALDH1A1 P00352 5/20 0.51
PDK2 Q15119 1/20 0.49
TRPM8 Q7Z2W7 1/20 0.49
PPARA Q07869 1/20 0.49
MAPT P10636 1/20 0.48
LMNA P02545 4/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
MAPK1 P28482 2/20 0.48
SMN1; SMN2 Q16637 6/20 0.47
HTT P42858 2/20 0.47
SRD5A2 P31213 1/20 0.47
KDM4E B2RXH2 1/20 0.46
THRB P10828 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13288123 0.91 POLB (0.54) POLBGAAMEN1KMT2ANPC1
SCHEMBL12998150 0.91 MEN1 (0.57) POLBGAAMEN1KMT2ANPC1
SCHEMBL22221533 0.87 POLB (0.62) POLBGAAMEN1KMT2ARAB9A
SCHEMBL25828187 0.85 POLB (0.57) POLBGAAMEN1KMT2ANPC1
SCHEMBL25828116 0.84 POLB (0.61) POLBGAAMEN1KMT2ANPC1
SCHEMBL278876 0.79 THRB (0.52) POLBGAAMEN1KMT2ANPC1
SCHEMBL25829502 0.79 POLB (0.61) POLBMEN1KMT2ANPC1RAB9A
SCHEMBL38789 0.77 ALOX15 (0.70) GAAMEN1KMT2AALDH1A1PPARA
SCHEMBL4536225 0.77 GAA (0.69) GAAALDH1A1PPARAMAPTLMNA
SCHEMBL25828205 0.76 POLB (0.59) POLBMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2199273-B1 Polymerizable photoinitiators and radiation curable compositions AGFA NV (BE) 2018-02-21 EP disclosed
EP-2199273-B1 Polymerizable photoinitiators and radiation curable compositions AGFA NV (BE) 2018-02-21 EP disclosed
US-8492452-B2 Polymerizable photoinitiators and radiation curable compositions AGFA GRAPHICS NV (BE) 2013-07-23 US disclosed
US-8492452-B2 Polymerizable photoinitiators and radiation curable compositions AGFA GRAPHICS NV (BE) 2013-07-23 US disclosed
US-8492452-B2 Polymerizable photoinitiators and radiation curable compositions AGFA GRAPHICS NV (BE) 2013-07-23 US disclosed
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2011-09-15 US disclosed
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2011-09-15 US disclosed
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2011-09-15 US disclosed
WO-2010069758-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2010-06-24 WO disclosed
EP-2199273-A1 Polymerizable photoinitiators and radiation curable compositions AGFA Graphics NV (BE) 2010-06-23 EP disclosed
EP-2199273-A1 Polymerizable photoinitiators and radiation curable compositions AGFA Graphics NV (BE) 2010-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS WEE1, ZYX, MTR POLB 1031/4885GAA 4112/4885MEN1 1101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.