Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661508 | 0.81 | ALDH1A1 (0.46) | MTNR1AMTNR1BPOLBKDM4EALDH1A1 | |
| SCHEMBL11090 | 0.81 | SIGMAR1 (0.49) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL21660832 | 0.79 | KDM4E (0.41) | NQO2MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL24276406 | 0.78 | SIGMAR1 (0.57) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL22255154 | 0.76 | SIGMAR1 (0.39) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL9891794 | 0.76 | SIGMAR1 (0.60) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL22519387 | 0.76 | MEN1 (0.47) | SIGMAR1NQO2MTNR1AMTNR1BKDM4E | |
| SCHEMBL24333751 | 0.75 | SIGMAR1 (0.38) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL9891910 | 0.74 | SIGMAR1 (0.43) | SIGMAR1BCHENQO2MTNR1AMTNR1B | |
| SCHEMBL12413657 | 0.74 | SIGMAR1 (0.57) | SIGMAR1BCHENQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | SIGMAR1 430/4885BCHE 4738/4885NQO2 3177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.