Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | PYGM | P11217 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867575 | 0.89 | PYGM (0.51) | ALDH1A1KDM4ETSHRHPGDLMNA | |
| SCHEMBL23859942 | 0.83 | POLB (0.55) | ALDH1A1KDM4ETSHRHPGDSMN1; SMN2 | |
| SCHEMBL23867511 | 0.81 | PYGM (0.53) | ALDH1A1TSHRHPGDSMN1; SMN2PYGM | |
| SCHEMBL30979648 | 0.76 | POLB (0.66) | ALDH1A1KDM4ETSHRHPGDSMN1; SMN2 | |
| SCHEMBL23867573 | 0.75 | PYGM (0.51) | ALDH1A1HPGDSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL23867479 | 0.73 | POLB (0.49) | ALDH1A1KDM4ETSHRHPGDSMN1; SMN2 | |
| SCHEMBL11506640 | 0.73 | GALR2 (0.66) | KDM4ELMNAMAPK1MAPT | |
| SCHEMBL23867576 | 0.72 | LMNA (0.52) | ALDH1A1KDM4ETSHRHPGDSMN1; SMN2 | |
| SCHEMBL31094223 | 0.72 | CCNE1 (0.48) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL23867509 | 0.72 | CCNE1 (0.50) | ALDH1A1KDM4EHPGDLMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |