Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867551 | 0.93 | LMNA (0.61) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL31094233 | 0.89 | PKM (0.50) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL31094221 | 0.86 | LMNA (0.49) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL23859942 | 0.86 | POLB (0.55) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL31094223 | 0.84 | CCNE1 (0.48) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL31094226 | 0.81 | MAPT (0.44) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL30979648 | 0.81 | POLB (0.66) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL23867649 | 0.80 | ALDH1A1 (0.52) | LMNAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL23867579 | 0.79 | SRC (0.40) | HSD17B10ALDH1A1KDM4EMAPTSLC2A1 | |
| SCHEMBL31094238 | 0.78 | SLC2A1 (0.50) | LMNAHSD17B10ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |