Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867576 | 0.93 | LMNA (0.52) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL30979648 | 0.88 | POLB (0.66) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL31094233 | 0.83 | PKM (0.50) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL31094221 | 0.80 | LMNA (0.49) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL23859942 | 0.80 | POLB (0.55) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL23867487 | 0.80 | MAPT (0.67) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL31094223 | 0.78 | CCNE1 (0.48) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL30234299 | 0.77 | LMNA (0.65) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL23867479 | 0.75 | POLB (0.49) | LMNAMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL31094226 | 0.75 | MAPT (0.44) | LMNAMAPTALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |