Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30979648 | 0.82 | POLB (0.66) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL23867551 | 0.80 | LMNA (0.61) | MAPTKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL31094224 | 0.78 | SLC2A1 (0.51) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL30234299 | 0.75 | LMNA (0.65) | MAPTKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL31094227 | 0.75 | SLC2A1 (0.44) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL23859942 | 0.74 | POLB (0.55) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL23867524 | 0.74 | HCRTR1 (0.52) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL23867523 | 0.74 | SLC2A1 (0.49) | MAPTKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL23867576 | 0.73 | LMNA (0.52) | MAPTKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL30979651 | 0.72 | SLC2A1 (0.51) | MAPTKDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |