Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23859943 | 0.83 | HRH3 (0.53) | MAPTLMNACCNE1CDK2KDM4E | |
| SCHEMBL30165658 | 0.83 | HRH3 (0.53) | MAPTLMNACCNE1CDK2KDM4E | |
| SCHEMBL23867509 | 0.80 | CCNE1 (0.50) | MAPTLMNACCNE1CDK2KDM4E | |
| SCHEMBL30979651 | 0.80 | SLC2A1 (0.51) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL31094226 | 0.78 | MAPT (0.44) | MAPTPOLBLMNANPSR1CCNE1 | |
| SCHEMBL23867651 | 0.77 | LMNA (0.53) | MAPTPOLBL3MBTL1LMNANPSR1 | |
| SCHEMBL23867523 | 0.75 | SLC2A1 (0.49) | MAPTLMNACCNE1CDK2KDM4E | |
| SCHEMBL23867521 | 0.74 | HTR1A (0.50) | LMNACCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL23867468 | 0.73 | HRH3 (0.45) | MAPTMEN1KMT2ALMNANPSR1 | |
| SCHEMBL30234371 | 0.73 | ROCK1 (0.46) | MAPTL3MBTL1LMNACCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |