Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | GALR2 | O43603 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GALR1 | P47211 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11506640 | 0.86 | GALR2 (0.66) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL18087209 | 0.79 | LMNA (0.57) | MAPTLMNAMAPK1TAAR1POLB | |
| SCHEMBL23867651 | 0.78 | LMNA (0.53) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL23867667 | 0.77 | LMNA (0.46) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL18063516 | 0.77 | LMNA (0.72) | MAPTLMNAMAPK1TAAR1POLB | |
| SCHEMBL20042176 | 0.76 | ROCK2 (0.67) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL23867649 | 0.76 | ALDH1A1 (0.52) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL30234817 | 0.76 | LMNA (0.52) | MAPTLMNAGALR2MAPK1TAAR1 | |
| SCHEMBL12218261 | 0.76 | RAB9A (0.76) | MAPTPOLBROCK2MEN1GAA | |
| SCHEMBL3245932 | 0.75 | GALR2 (0.61) | MAPTLMNAGALR2NPSR1GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118338898-A | Small molecule inhibitors of oncogenic CHD1L with preclinical anti-colorectal cancer activity | 科罗拉多州立大学董事会（法人团体） | 2024-07-12 | — | — | CN | disclosed |
| US-20230103444-A1 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | UNITED STATES GOVERNMENT | 2023-04-06 | — | — | US | disclosed |
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |
| EP-4127209-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-02-08 | — | — | EP | disclosed |
| CN-115667553-A | Small molecule inhibitors of oncogenic CHD1L with preclinical activity against colorectal cancer | 科罗拉多州立大学董事会法人团体 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103444-A1 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | CHD1L, CHD1, CHD9 | MAPT 2751/4885LMNA 3833/4885GALR2 3081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.