Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GALR2 | O43603 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | GALR1 | P47211 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23859940 | 0.77 | MAPT (0.62) | LMNAMAPTGALR2ALDH1A1MAPK1 | |
| SCHEMBL11506640 | 0.71 | GALR2 (0.66) | LMNAMAPTGALR2MAPK1TAAR1 | |
| SCHEMBL1708189 | 0.70 | KMT2A (0.56) | MAPTALDH1A1MAPK1NPSR1HSD17B10 | |
| SCHEMBL22148449 | 0.69 | HRH4 (0.58) | ALDH1A1NPSR1HSD17B10KDM4EGBA1 | |
| SCHEMBL30788620 | 0.69 | HRH4 (0.58) | ALDH1A1NPSR1HSD17B10KDM4EGBA1 | |
| SCHEMBL13693076 | 0.68 | KMT2A (0.55) | LMNAMAPTALDH1A1MAPK1NPSR1 | |
| SCHEMBL13033934 | 0.66 | KMT2A (0.56) | MAPTALDH1A1MAPK1POLBNPSR1 | |
| SCHEMBL23867651 | 0.65 | LMNA (0.53) | LMNAMAPTGALR2ALDH1A1MAPK1 | |
| SCHEMBL17303793 | 0.65 | ALDH1A1 (0.54) | LMNAMAPTALDH1A1MAPK1TAAR1 | |
| SCHEMBL15830164 | 0.64 | ALDH1A1 (0.52) | LMNAMAPTALDH1A1MAPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |