SCHEMBL238751

SCHEMBL238751

O=c1cc(C(F)(F)F)c2ccc(OCc3ccccc3)cc2o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
AR P10275 16/20 1.00
MAOB P27338 2/20 0.78
AGER Q15109 1/20 0.68
NPC1 O15118 1/20 0.67
MAOA P21397 1/20 0.67
CASP3 P42574 1/20 0.67
RAB9A P51151 1/20 0.67
SENP8 Q96LD8 1/20 0.67
SENP7 Q9BQF6 1/20 0.67
SENP6 Q9GZR1 1/20 0.67
TDP1 Q9NUW8 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29724625 0.93 AR (0.87) ARMAOB
SCHEMBL28448185 0.93 AR (0.87) ARMAOB
SCHEMBL1104918 0.91 AR (0.83) ARMAOBAGER
SCHEMBL29724499 0.89 AR (1.00) ARMAOBAGER
SCHEMBL29724376 0.89 AR (1.00) ARMAOBAGER
SCHEMBL28897388 0.89 AR (1.00) ARMAOBAGER
SCHEMBL28441293 0.89 AR (1.00) ARMAOBAGER
SCHEMBL29724359 0.88 AR (0.79) ARMAOBAGER
SCHEMBL1104924 0.88 AR (1.00) ARMAOBAGERNPC1CASP3
SCHEMBL29724494 0.88 AR (1.00) ARMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 410 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230392121-A1 HYDROGELS FOR CELL CULTURE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-12-07 US claimed
EP-4208534-A1 HYDROGELS FOR CELL CULTURE Katholieke Universiteit Leuven (BE) 2023-07-12 EP claimed
WO-2022049154-A1 HYDROGELS FOR CELL CULTURE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2022-03-10 WO claimed
US-20210077444-A1 Methods of Inducing Metabolic Maturation of Human Pluripotent Stem Cells-Derived Hepatocytes YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) 2021-03-18 US claimed
US-20170266145-A1 METHODS OF INDUCING METABOLIC MATURATION OF HUMAN PLURIPOTENT STEM CELLS-DERIVED HEPATOCYTES YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2017-09-21 US claimed
US-8952054-B2 Small molecule inhibitors of MUC1 and methods of identifying the same DANA-FARBER CANCER INSTITUTE, INC. (US) 2015-02-10 US claimed
EP-2548017-A2 SMALL MOLECULE INHIBITORS OF MUC1 AND METHODS OF IDENTIFYING THE SAME GENUS ONCOLOGY, LLC (US) 2013-01-23 EP claimed
US-20110251246-A1 SMALL MOLECULE INHIBITORS OF MUC1 AND METHODS OF IDENTIFYING THE SAME NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-10-13 US claimed
WO-2011115819-A2 SMALL MOLECULE INHIBITORS OF MUC1 AND METHODS OF IDENTIFYING THE SAME GENUS ONCOLOGY, LLC (US) 2011-09-22 WO claimed
US-20040106216-A1 Method of measuring drug-metabolizing enzyme activity, method of evaluating inhibition of drug-metabolizing enzyme activity, and composition for these methods TOYO BOSEKI KABUSHIKI KAISHA (JP) 2004-06-03 US claimed
EP-1378751-A2 Method of measuring drug-metabolizing enzyme activity, method of evaluating inhibition of drug-metabolizing enzyme activity, and composition for these methods Toyo Boseki Kabushiki Kaisha (JP) 2004-01-07 EP claimed
US-12630804-B2 Blood brain barrier model University of Lancashire (GB) 2026-05-19 US disclosed
US-20260083728-A1 COMPOUNDS FOR TREATING INFECTIONS WITH PARASITIC PROTOZOA OHIO STATE INNOVATIION FOUND (US) 2026-03-26 US disclosed
US-12466895-B2 Antibodies against the MUC1-c/extracellular domain (MUC1-C/ECD) DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-11-11 US disclosed
EP-4590676-A1 HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE Neurocrine Biosciences, Inc. (US) 2025-07-30 EP disclosed
WO-2001049663-A2 NON-PEPTIDE INHIBITION OF T-LYMPHOCYTE ACTIVATION AND THERAPIES RELATED THERETO THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-07-12 WO disclosed
US-6207404-B1 SUBJECTING THE CYTOCHROME P450 ENZYME AND THE COUMARIN BASED COMPOUND TO CONDITIONS WHEREBY THE CYTOCHROME P450 ENZYME CATALYZES THE CONVERSION OF THE COUMARIN BASED COMPOUND TO A FLUORESCENT PRODUCT GENTEST CORPORATION 2001-03-27 US disclosed
WO-2001020025-A2 POLYMORPHISMS IN THE HUMAN CYP3A4 AND CYP3A7 GENES AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS EPIDAUROS BIOTECHNOLOGIE AG (DE) 2001-03-22 WO disclosed
US-6143492-A COMPOUND USEFUL AS AN OPTICAL PROBE; DRUG SCREENING AURORA BIOSCIENCES CORPORATION (US) 2000-11-07 US disclosed
WO-2000035900-A1 OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY AURORA BIOSCIENCES CORPORATION (US) 2000-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110251246-A1 SMALL MOLECULE INHIBITORS OF MUC1 AND METHODS OF IDENTIFYING THE SAME MUC1, EPCAM, CD44 AR 4148/4885MAOB 4859/4885AGER 1087/4885
US-12630804-B2 Blood brain barrier model PGF, FLT4, VEGFA AR 3253/4885MAOB 4481/4885AGER 1120/4885
US-20260083728-A1 COMPOUNDS FOR TREATING INFECTIONS WITH PARASITIC PROTOZOA CLIC1, AOC2, CFTR AR 3814/4885MAOB 1576/4885AGER 4697/4885
US-12466895-B2 Antibodies against the MUC1-c/extracellular domain (MUC1-C/ECD) MUC1, EPCAM, SDC1 AR 2221/4885MAOB 4870/4885AGER 2657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.