Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867171 | 0.85 | KDM4E (0.46) | HPGDSHTR1ADRD2DRD4HTR2A | |
| SCHEMBL20322499 | 0.83 | CHRM4 (0.40) | HPGDSHTR1ADRD2DRD4HTR2A | |
| Trifluoroacetic Acid SCHEMBL30349693 | 0.82 | OPRM1 (0.48) | HPGDSCACNA2D1CACNA1BCACNB1OPRM1 | |
| SCHEMBL19600790 | 0.80 | HPGDS (0.50) | HPGDSDRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL27366890 | 0.79 | DRD2 (0.46) | CACNA2D1CACNA1BCACNB1HTR1ADRD2 | |
| SCHEMBL27366339 | 0.76 | PDE10A (0.47) | CACNA2D1CACNA1BCACNB1HTR1ADRD2 | |
| SCHEMBL23594261 | 0.75 | KDM2B (0.47) | CACNA2D1CACNA1BCACNB1HRH3ALDH1A1 | |
| SCHEMBL24003534 | 0.74 | ALDH1A1 (0.47) | HPGDSHRH3ALDH1A1NPC1RAB9A | |
| SCHEMBL30863341 | 0.74 | GPR119 (0.41) | CACNA2D1CACNA1BCACNB1DRD2HTR2A | |
| SCHEMBL24003533 | 0.74 | ALDH1A1 (0.49) | HTR1ADRD2DRD4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |