Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588648 | 0.87 | GAA (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9515290 | 0.83 | TBXAS1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9515296 | 0.83 | TBXAS1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3637129 | 0.81 | MAPT (0.60) | HPGDALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10350136 | 0.81 | MAPT (0.60) | HPGDALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1405662 | 0.81 | MAPT (0.60) | HPGDALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2392661 | 0.81 | KMT2A (0.47) | ALDH1A1MEN1KMT2APKM | |
| SCHEMBL1907796 | 0.79 | DPEP1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2394174 | 0.79 | DPEP1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29279528 | 0.78 | PRKDC (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |