Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | PRKACG | P22612 | 1/20 | 0.32 |
| ▸ | PRKACB | P22694 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19877263 | 0.84 | CYP11B2 (0.35) | SRCCSNK1A1CLK4MAP3K8EGFR | |
| SCHEMBL23899063 | 0.84 | SRC (0.36) | SRCCSNK1A1CLK4MAP3K8EGFR | |
| SCHEMBL22301636 | 0.77 | CYP11B2 (0.35) | SRCCSNK1A1CLK4MAP3K8EGFR | |
| SCHEMBL30721099 | 0.77 | CYP11B2 (0.35) | SRCCSNK1A1CLK4MAP3K8EGFR | |
| SCHEMBL4960627 | 0.75 | VCAM1 (0.47) | EGFRALDH1A1TDP1 | |
| SCHEMBL29354755 | 0.75 | VCAM1 (0.47) | EGFRALDH1A1TDP1 | |
| SCHEMBL23899035 | 0.75 | EGFR (0.50) | EGFR | |
| SCHEMBL529236 | 0.74 | SRC (0.44) | SRCEGFRCHEK1ALDH1A1 | |
| SCHEMBL31251508 | 0.72 | KDM4E (0.31) | ALDH1A1 | |
| SCHEMBL20570729 | 0.71 | MAP3K8 (0.32) | MAP3K8EGFRCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021202688-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. (US) | 2021-10-07 | — | — | WO | disclosed |