Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 4/20 | 0.49 |
| ▸ | PLG | P00747 | 3/20 | 0.49 |
| ▸ | PLAU | P00749 | 3/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.49 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901812 | 0.82 | F2 (0.57) | KLK1KLK5F2PLGPLAU | |
| SCHEMBL34433937 | 0.82 | F2 (0.57) | KLK1KLK5F2PLGPLAU | |
| SCHEMBL7477294 | 0.76 | APEX1 (0.44) | F2PLGPLAUPRSS1F10 | |
| SCHEMBL1638544 | 0.76 | MAPT (0.54) | MAPTJAK2JAK1TYK2JAK3 | |
| SCHEMBL7476301 | 0.71 | KLK1 (0.53) | KLK1KLK5F2PLGPLAU | |
| SCHEMBL3643686 | 0.71 | AGTR1 (0.53) | HDAC6 | |
| SCHEMBL7373376 | 0.71 | F10 (0.46) | F2PLGPLAUPRSS1F10 | |
| SCHEMBL24095240 | 0.71 | MAPT (0.44) | MAPTHDAC6 | |
| SCHEMBL7408823 | 0.70 | F10 (0.59) | KLK1KLK5F2PLGPLAU | |
| SCHEMBL1726103 | 0.69 | JAK2 (0.58) | F2MAPTJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | PAM, AMPD1, AMPD3 | KLK1 1869/4885KLK5 2259/4885F2 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.