Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 3/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30479924 | 1.00 | ALOX5 (0.40) | ALOX5IMPDH1IMPDH2APP | |
| SCHEMBL23909143 | 0.98 | ALOX5 (0.37) | ALOX5IMPDH1IMPDH2APP | |
| SCHEMBL30479925 | 0.98 | ALOX5 (0.37) | ALOX5IMPDH1IMPDH2APP | |
| SCHEMBL26969207 | 0.84 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL7413599 | 0.84 | ALOX5 (0.41) | ALOX5IMPDH1IMPDH2 | |
| SCHEMBL7325280 | 0.84 | ALOX5 (0.41) | ALOX5IMPDH1IMPDH2 | |
| SCHEMBL30479929 | 0.84 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL23888077 | 0.84 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL1241214 | 0.84 | ALOX5 (0.41) | ALOX5IMPDH1IMPDH2 | |
| SCHEMBL23903832 | 0.83 | ALOX5 (0.46) | ALOX5IMPDH1IMPDH2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400588-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-12-05 | — | — | US | disclosed |
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-16 | — | — | US | disclosed |
| CN-115996916-A | Compositions and methods for preventing and/or treating mitochondrial diseases including friedreich ataxia | 康德生物医疗有限公司 | 2023-04-21 | — | — | CN | disclosed |
| US-20210317146-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-10-14 | — | — | US | disclosed |
| US-20210317146-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-10-14 | — | — | US | disclosed |
| WO-2021202986-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS CORP (MC) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | ALOX5 1404/4885IMPDH1 1351/4885IMPDH2 1548/4885 |
| US-20240400588-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | ALOX5 1404/4885IMPDH1 1351/4885IMPDH2 1548/4885 |
| US-20210317146-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | ALOX5 1404/4885IMPDH1 1351/4885IMPDH2 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.