Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 4/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1241214 | 1.00 | ALOX5 (0.41) | ALOX5LMNAPGRCYP3A4CYP2D6 | |
| SCHEMBL7413599 | 1.00 | ALOX5 (0.41) | ALOX5LMNAPGRCYP3A4CYP2D6 | |
| SCHEMBL7323576 | 0.98 | ALOX5 (0.38) | ALOX5LMNAPGRCYP3A4CYP2D6 | |
| SCHEMBL8293476 | 0.92 | TNKS2 (0.41) | ALOX5LMNAPGRCYP3A4CYP2D6 | |
| SCHEMBL7361916 | 0.86 | IMPDH2 (0.46) | ALOX5TDP1IMPDH1IMPDH2TNKS2 | |
| SCHEMBL23888077 | 0.85 | ALOX5 (0.55) | ALOX5MAPTTDP1 | |
| SCHEMBL30479929 | 0.85 | ALOX5 (0.55) | ALOX5MAPTTDP1 | |
| SCHEMBL26969207 | 0.85 | ALOX5 (0.55) | ALOX5MAPTTDP1 | |
| SCHEMBL22579083 | 0.84 | ALOX5 (0.40) | ALOX5IMPDH1IMPDH2 | |
| SCHEMBL13736907 | 0.84 | ALOX5 (0.40) | ALOX5IMPDH1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2911656-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2020-12-02 | — | — | EP | disclosed |
| US-20170246195-A1 | MITOQUINONE DERIVATIVES USED AS MITOCHONDRIALLY TARGETED ANTIOXIDANTS | ANTIPODEAN PHARMACEUTICALS INC (NZ) | 2017-08-31 | — | — | US | disclosed |
| US-9446015-B2 | Quinone based nitric oxide donating compounds for ophthalmic use | NICOX SCIENCE IRELAND (IE) | 2016-09-20 | — | — | US | disclosed |
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2015-10-08 | — | — | US | disclosed |
| EP-2911656-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | Nicox Science Ireland (IE) | 2015-09-02 | — | — | EP | disclosed |
| US-9079821-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-07-14 | — | — | US | disclosed |
| US-9061962-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-06-23 | — | — | US | disclosed |
| EP-2707354-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SCIENCE IRELAND (IE) | 2015-04-29 | — | — | EP | disclosed |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2014-11-20 | — | — | US | disclosed |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SA (FR) | 2014-05-15 | — | — | US | disclosed |
| WO-2014063923-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX S.A. (FR) | 2014-05-01 | — | — | WO | disclosed |
| EP-2722326-A1 | Quinone based nitric oxide donating compounds | NICOX S.A. (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2707354-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | Nicox S.A. (FR) | 2014-03-19 | — | — | EP | disclosed |
| WO-2013060673-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2013-05-02 | — | — | WO | disclosed |
| US-4525361-A | FOR PHYSIOLOGICAL HOST DEFENSE CONTROL ACTIVITY IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4407757-A | IMMUNOLOGY AGENT, MUSCLE RELAXANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-10-04 | — | — | US | disclosed |
| US-4271083-A | IMMUNO-POTENTIATING ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-06-02 | — | — | US | disclosed |
| US-4139545-A | IMMUNO-POTENTIATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1979-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246195-A1 | MITOQUINONE DERIVATIVES USED AS MITOCHONDRIALLY TARGETED ANTIOXIDANTS | PRDX5, TXN2, MT-ND2 | ALOX5 546/4885LMNA 1460/4885PGR 2484/4885 |
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NOS1, NOS3, NOS2 | ALOX5 183/4885LMNA 2979/4885PGR 3899/4885 |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | ALOX5 189/4885LMNA 2252/4885PGR 3698/4885 |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | ALOX5 189/4885LMNA 2252/4885PGR 3698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.