Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | PTAFR | P25105 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927136 | 0.86 | CYP3A4 (0.37) | CYP3A4OPRK1HPGDPTAFRKDM4E | |
| SCHEMBL30202046 | 0.86 | CYP3A4 (0.37) | CYP3A4OPRK1HPGDPTAFRKDM4E | |
| SCHEMBL23927159 | 0.85 | PTAFR (0.47) | OPRK1HPGDP2RX7PTAFRSMN1; SMN2 | |
| SCHEMBL30201943 | 0.79 | P2RX7 (0.43) | OPRK1HPGDP2RX7PTAFRGABRA1 | |
| SCHEMBL23927185 | 0.79 | P2RX7 (0.43) | OPRK1HPGDP2RX7PTAFRGABRA1 | |
| SCHEMBL23881464 | 0.78 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL10404510 | 0.78 | CYP3A4 (0.56) | CYP3A4OPRK1HPGDPTAFRKDM4E | |
| SCHEMBL26096855 | 0.78 | SLC22A1 (0.33) | CYP3A4OPRK1P2RX7PTAFRGABRA1 | |
| SCHEMBL23927126 | 0.78 | PTAFR (0.46) | OPRK1HPGDPTAFRSMN1; SMN2GABRA1 | |
| SCHEMBL23927114 | 0.77 | OPRK1 (0.43) | OPRK1P2RX7PTAFRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309664-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309664-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRG1 | CYP3A4 223/4885OPRK1 65/4885HPGD 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.