Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23900434 | 0.73 | THRB (0.44) | THRBEPHX2HSD11B1L3MBTL1 | |
| SCHEMBL3817644 | 0.71 | MAPT (0.39) | ALDH1A1 | |
| SCHEMBL23916972 | 0.69 | ALDH1A1 (0.43) | THRBALDH1A1 | |
| SCHEMBL4404236 | 0.68 | EPHX2 (0.52) | THRBEPHX2HSD11B1 | |
| SCHEMBL4784023 | 0.65 | RAB9A (0.66) | ALDH1A1 | |
| SCHEMBL23908019 | 0.65 | ALDH1A1 (0.47) | THRBEPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL3456922 | 0.64 | MEN1 (0.61) | HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL15611303 | 0.64 | GAA (0.36) | ALDH1A1 | |
| SCHEMBL23900450 | 0.62 | THRB (0.42) | THRBEPHX2HSD11B1L3MBTL1 | |
| SCHEMBL23907993 | 0.60 | THRB (0.45) | THRBEPHX2HSD11B1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11932626-B2 | 2-pyrimidone analogs as potent antiviral agents against Alphaviruses | SOUTHERN RESEARCH INSTITUTE (US) | 2024-03-19 | — | — | US | disclosed |
| US-20230120566-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | OREGON HEALTH AND SCIENCE UNIVERSITY | 2023-04-20 | — | — | US | disclosed |
| CN-115916175-A | Novel 2-pyrimidinone analogs as potent antiviral agents against alphaviruses | 南方研究院 | 2023-04-04 | — | — | CN | disclosed |
| US-11566019-B2 | 2-pyrimidone analogs as potent antiviral agents against alphaviruses | SOUTHERN RESEARCH INSTITUTE (US) | 2023-01-31 | — | — | US | disclosed |
| US-20220177452-A9 | 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-09 | — | — | US | disclosed |
| US-20210317106-A1 | 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | SOUTHERN RES INST (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317106-A1 | 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | THRB 3748/4885EPHX2 645/4885HSD11B1 4069/4885 |
| US-11566019-B2 | 2-pyrimidone analogs as potent antiviral agents against alphaviruses | EIF2AK2, ZC3HAV1, MAVS | THRB 3748/4885EPHX2 645/4885HSD11B1 4069/4885 |
| US-11932626-B2 | 2-pyrimidone analogs as potent antiviral agents against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | THRB 3748/4885EPHX2 645/4885HSD11B1 4069/4885 |
| US-20220177452-A9 | 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | THRB 3748/4885EPHX2 645/4885HSD11B1 4069/4885 |
| US-20230120566-A1 | Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses | EIF2AK2, ZC3HAV1, MAVS | THRB 3761/4885EPHX2 608/4885HSD11B1 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.