SCHEMBL23908293

SCHEMBL23908293

Cc1cc(Nc2ccc(C(C)(C)C)cc2)c(Cl)c(Nc2ccc(C(C)(C)C)cc2)c1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.43
SLC2A1 P11166 1/20 0.43
AKR1C3 P42330 2/20 0.42
AKR1C2 P52895 2/20 0.42
HSD17B2 P37059 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
DHODH Q02127 2/20 0.37
CSNK1D P48730 2/20 0.37
CSNK1G2 P78368 2/20 0.37
CSNK1A1 P48729 1/20 0.37
GSK3B P49841 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22051005 0.92 SLC2A1 (0.40) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL22060593 0.92 RAPGEF4 (0.44) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL23589544 0.89 AKR1C3 (0.44) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL29454091 0.89 MAPT (0.39) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL23589605 0.84 SLC2A1 (0.42) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL29292631 0.84 SLC2A1 (0.36) TSHRSLC2A1AKR1C3AKR1C2HSD17B2
SCHEMBL29292712 0.84 FGFR2 (0.44) SLC2A1AKR1C3AKR1C2NPC1RAB9A
SCHEMBL30574528 0.84 RAPGEF4 (0.40) TSHRHSD17B2
SCHEMBL24178525 0.81 RAB9A (0.42) TSHRSLC2A1AKR1C3AKR1C2NPC1
SCHEMBL23908291 0.81 RAPGEF4 (0.45) RAB9ASMN1; SMN2ALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11845768-B2 Polycyclic compound and organic light-emitting device including same LG CHEM, LTD. (KR) 2023-12-19 US disclosed
CN-112585145-B Polycyclic compound and organic light emitting device including the same 株式会社LG化学 2023-09-29 CN disclosed
US-20210317147-A1 POLYCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME LG CHEM, LTD. (KR) 2021-10-14 US disclosed
US-20210317147-A1 POLYCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME LG CHEM, LTD. (KR) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210317147-A1 POLYCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME CYP1A1, CRY1, CYP1B1 TSHR 4541/4885SLC2A1 4640/4885AKR1C3 1070/4885
US-11845768-B2 Polycyclic compound and organic light-emitting device including same CRY1, CYP1A1, CRY2 TSHR 4473/4885SLC2A1 4421/4885AKR1C3 1229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.