Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | FNTA | P49354 | 7/20 | 0.50 |
| ▸ | FNTB | P49356 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | SQLE | Q14534 | 2/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310923 | 1.00 | KMT2A (0.52) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL10297991 | 1.00 | KMT2A (0.52) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL23887967 | 0.87 | HPGD (0.49) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL23903835 | 0.87 | FNTA (0.38) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL9609390 | 0.83 | ALDH1A1 (0.38) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL23888067 | 0.81 | LSS (0.59) | — | |
| SCHEMBL3193242 | 0.80 | ALOX15 (0.56) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL12997108 | 0.80 | ALOX15 (0.56) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL3751814 | 0.80 | ALOX15 (0.56) | KMT2AFNTAFNTBALOX15ALDH1A1 | |
| SCHEMBL3193249 | 0.80 | ALOX15 (0.56) | KMT2AFNTAFNTBALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400588-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-12-05 | — | — | US | disclosed |
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-16 | — | — | US | disclosed |
| CN-115996916-A | Compositions and methods for preventing and/or treating mitochondrial diseases including friedreich ataxia | 康德生物医疗有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-4126836-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | Stealth BioTherapeutics Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20210317146-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037350-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | KMT2A 2676/4885FNTA 1919/4885FNTB 1630/4885 |
| US-20240400588-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | KMT2A 2676/4885FNTA 1919/4885FNTB 1630/4885 |
| US-20210317146-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | KMT2A 2676/4885FNTA 1919/4885FNTB 1630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.