SCHEMBL23916498

SCHEMBL23916498

CS(=O)(=O)c1ccc(-c2ccc(N)cc2-c2nnn[nH]2)cn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 2/20 0.40
PIK3CD O00329 1/20 0.40
PIP5K1C O60331 1/20 0.40
PIK3CB P42338 1/20 0.40
PI4KA P42356 1/20 0.40
PIK3CG P48736 1/20 0.40
MAP4K4 O95819 3/20 0.36
FYN P06241 3/20 0.36
MINK1 Q8N4C8 2/20 0.36
TNIK Q9UKE5 1/20 0.36
KCNH2 Q12809 3/20 0.35
PIK3CA P42336 1/20 0.35
CDK9 P50750 1/20 0.34
POLQ O75417 1/20 0.34
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA4 P22748 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23916420 0.82 HPGDS (0.36) PI4KBPIK3CDPIK3CBPI4KAPIK3CG
SCHEMBL23916396 0.79 PIK3CG (0.39) PI4KBPIK3CDPIK3CBPI4KAPIK3CG
SCHEMBL23915989 0.79 PDE3B (0.31) MAP4K4
SCHEMBL20329236 0.79 KCNH2 (0.41) PI4KBPIK3CDPIP5K1CPIK3CBPI4KA
SCHEMBL23910009 0.79 MAP3K11 (0.41) PIK3CAATRATRIP
SCHEMBL20329856 0.77 PIK3CA (0.40) PI4KBPIK3CDPIK3CBPI4KAPIK3CG
SCHEMBL23915977 0.77 KCNH2 (0.35) PI4KBMAP4K4MINK1KCNH2PIK3CA
SCHEMBL23916505 0.76 FEN1 (0.30)
SCHEMBL21135415 0.76 KCNH2 (0.41) PI4KBPIK3CDPIK3CBPI4KAPIK3CG
SCHEMBL23916415 0.76 PIK3CD (0.41) PI4KBPIK3CDPIK3CBPI4KAFYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210317092-A1 TETRAZOLE CONTAINING COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210317092-A1 TETRAZOLE CONTAINING COMPOUNDS TSLP, IL5, TRPA1 PI4KB 3755/4885PIK3CD 3809/4885PIP5K1C 2371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.