Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609803 | 0.91 | TP53 (0.48) | ADRA2CHTR3AALDH1A1TP53TDP1 | |
| SCHEMBL3584889 | 0.86 | ADRA2C (0.61) | ADRA2CHTR3AAGXTALDH1A1HDAC3 | |
| SCHEMBL607917 | 0.85 | ALDH1A1 (0.47) | ADRA2CAGXTALDH1A1TP53TDP1 | |
| SCHEMBL29442412 | 0.84 | ALDH1A1 (0.64) | ADRA2CHTR3AAGXTALDH1A1HDAC3 | |
| SCHEMBL1444185 | 0.84 | ALDH1A1 (0.64) | ADRA2CHTR3AAGXTALDH1A1HDAC3 | |
| SCHEMBL816394 | 0.84 | PRMT6 (0.46) | ADRA2CAGXTALDH1A1HDAC4TP53 | |
| SCHEMBL609136 | 0.84 | PRMT6 (0.46) | ADRA2CAGXTALDH1A1HDAC4TP53 | |
| SCHEMBL23048845 | 0.83 | ADRA2C (0.57) | ADRA2CHTR3AAGXTALDH1A1HDAC3 | |
| SCHEMBL12367112 | 0.81 | TDP1 (0.42) | ADRA2CALDH1A1TP53TDP1GAA | |
| SCHEMBL4769361 | 0.81 | LMNA (0.53) | AGXTALDH1A1MAPTHTTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| US-9078909-B2 | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |