Sugi Predict

Sugi Predict / Compounds / SCHEMBL239206

SCHEMBL239206

SCHEMBL239206

[c]1ccc(-n2ccnc2)nc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LOXL2 Q9Y4K0 1/20 0.42
▸ CYP3A4 P08684 11/20 0.41
▸ LMNA P02545 3/20 0.39
▸ MAPT P10636 3/20 0.39
▸ ENPP2 Q13822 1/20 0.39
▸ MKNK1 Q9BUB5 1/20 0.39
▸ MKNK2 Q9HBH9 1/20 0.39
▸ NOTUM Q6P988 1/20 0.39
▸ CYP1A2 P05177 9/20 0.39
▸ CYP2D6 P10635 8/20 0.39
▸ HSD17B10 Q99714 5/20 0.39
▸ TDP1 Q9NUW8 4/20 0.39
▸ ALDH1A1 P00352 3/20 0.39
▸ MAPK1 P28482 3/20 0.39
▸ CYP2C19 P33261 8/20 0.39
▸ CYP2C9 P11712 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ ALOX15 P16050 6/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CLK4 Q9HAZ1 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2397043 0.76 — —
SCHEMBL1235012 0.76 POLB (0.31) —
SCHEMBL161573 0.72 CYP3A4 (0.63) CYP3A4LMNAMAPTENPP2MKNK1
SCHEMBL244687 0.72 LMNA (0.43) LOXL2CYP3A4LMNAMAPTENPP2
SCHEMBL10468221 0.72 LOXL2 (0.44) LOXL2CYP3A4LMNAMAPTENPP2
SCHEMBL8655805 0.71 CYP3A4 (0.47) LOXL2CYP3A4LMNAMAPTENPP2
SCHEMBL29401947 0.71 CYP3A4 (0.55) LOXL2CYP3A4LMNAMAPTCYP1A2
SCHEMBL117382 0.71 CYP3A4 (0.55) LOXL2CYP3A4LMNAMAPTCYP1A2
SCHEMBL28046790 0.71 CYP3A4 (0.61) CYP3A4LMNAMAPTENPP2MKNK1
SCHEMBL27862724 0.71 CYP3A4 (0.61) CYP3A4LMNAMAPTENPP2MKNK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US claimed
CN-113164458-A Monoacylglycerol lipase modulators 詹森药业有限公司 2021-07-23 — — CN claimed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP claimed
CN-108135172-B Probes for imaging huntingtin CHDI基金会股份有限公司 2021-03-30 — — CN claimed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US claimed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US claimed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US claimed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US claimed
EP-3340796-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2018-07-04 — — EP claimed
WO-2017040336-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2017-03-09 — — WO claimed
US-20060194837-A1 Tetrahydroisoquinoline compounds JANSSEN PHARMACEUTICA N.V. (BE) 2006-08-31 — — US claimed
JP-2006516145-A — — 2006-06-22 — — JP claimed
WO-2006066197-A1 TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS JANSSEN PHARMACEUTICA, N.V. (BE) 2006-06-22 — — WO claimed
CN-1741994-A 3-aminopyrrolidine derivatives as modulators of chemokine receptors INCYTE CORP (US) 2006-03-01 — — CN claimed
WO-2005085225-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-15 — — WO claimed
EP-1565436-A2 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2005-08-24 — — EP claimed
WO-2004050024-A2 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2004-06-17 — — WO claimed
CN-1259948-A 6,7-disubstituted-4-aminopyrido [2,3-D] pyrimidine compounds ABBOTT LAB (US) 2000-07-12 — — CN claimed
CN-1252070-A 5,7-disubstituted 4-aminopyrido [2,3,-d] pyrimidine compounds and their use as adenosine kinase inhibitors ABBOTT LAB (US) 2000-05-03 — — CN claimed
CN-1252069-A 5,6, 7-trisubstituted-4-aminopyrido [2, 3-d ] pyrimidine compounds ABBOTT LAB (US) 2000-05-03 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344637-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 LOXL2 4724/4885CYP3A4 4877/4885LMNA 2021/4885
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 LOXL2 4724/4885CYP3A4 4877/4885LMNA 2021/4885
US-20060194837-A1 Tetrahydroisoquinoline compounds HRH3, HRH4, HRH1 LOXL2 3522/4885CYP3A4 723/4885LMNA 4705/4885
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 LOXL2 4724/4885CYP3A4 4877/4885LMNA 2021/4885
US-10765764-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 LOXL2 4724/4885CYP3A4 4877/4885LMNA 2021/4885
US-10137211-B2 Probes for imaging Huntingtin protein HTT, HYPK, FABP7 LOXL2 4654/4885CYP3A4 4881/4885LMNA 1600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.