Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3773661 | 0.79 | AGTR2 (0.50) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL4524209 | 0.77 | HTR3E (0.47) | KDM4E | |
| SCHEMBL21997577 | 0.76 | CA2 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL5386962 | 0.74 | DRD2 (0.41) | CHRM2CHRM1CHRM3KDM4EALDH1A1 | |
| SCHEMBL21996912 | 0.74 | S1PR5 (0.40) | KMT2AMEN1 | |
| SCHEMBL12727212 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL25317215 | 0.73 | LMNA (0.46) | LMNAALDH1A1 | |
| SCHEMBL21044007 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL21044033 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL30218424 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |