Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.55 |
| ▸ | GABRP | O00591 | 3/20 | 0.55 |
| ▸ | GABRD | O14764 | 3/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.55 |
| ▸ | GABRE | P78334 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927197 | 0.86 | LMNA (0.51) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL25122961 | 0.84 | GABRA1 (0.49) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23927144 | 0.84 | GABRA1 (0.51) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30202083 | 0.84 | GABRA1 (0.51) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23927158 | 0.83 | CHRM1 (0.50) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23881540 | 0.82 | GABRA1 (0.49) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23881526 | 0.82 | LMNA (0.49) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30133111 | 0.82 | GABRA1 (0.49) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23927214 | 0.82 | LMNA (0.49) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30202074 | 0.80 | HTR5A (0.37) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139310-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021213952-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-28 | — | — | WO | disclosed |
| EP-3901155-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRB3 | GABRA1 1/4885GABRA5 9/4885GABRA3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.