Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.32 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.32 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927537 | 0.88 | APP (0.32) | — | |
| SCHEMBL23927529 | 0.88 | PSMB5 (0.34) | MAPTHTTALDH1A1 | |
| SCHEMBL23927534 | 0.88 | MT-CO2 (0.36) | MAPTPPARGPPARAMEN1ALDH1A1 | |
| SCHEMBL23927538 | 0.84 | KMT2A (0.33) | MAPTMEN1ALDH1A1KMT2ACYP2C19 | |
| SCHEMBL7113350 | 0.80 | RXRA (0.40) | MEN1KMT2A | |
| SCHEMBL7042573 | 0.75 | RXRA (0.36) | PPARGPPARA | |
| SCHEMBL14740813 | 0.73 | CCR2 (0.47) | MAPTTBXA2RTBXAS1MEN1ALDH1A1 | |
| SCHEMBL23927533 | 0.71 | MAPT (0.32) | MAPTALDH1A1 | |
| SCHEMBL14740772 | 0.71 | HCAR2 (0.44) | TBXA2RTBXAS1CYP2D6ALDH1A1PLOD2 | |
| SCHEMBL7109630 | 0.69 | CSF1R (0.38) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751095-B1 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | SANFORD BURNHAM MED RES INST (US) | 2021-10-27 | — | — | EP | disclosed |