Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.73 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258989 | 0.85 | KMT2A (1.00) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL23928513 | 0.84 | PTGS2 (0.72) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL23928576 | 0.82 | L3MBTL1 (0.77) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28358360 | 0.81 | PTGS2 (0.94) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL3447906 | 0.81 | PTGS2 (1.00) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL23928479 | 0.81 | KMT2A (0.70) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL11254624 | 0.80 | PTGS2 (0.80) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL23928527 | 0.80 | PTGS2 (0.80) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL11245208 | 0.80 | KMT2A (0.72) | KMT2AMEN1NLRP3PTGS2POLB | |
| SCHEMBL23928608 | 0.79 | PTGS2 (0.72) | KMT2AMEN1NLRP3PTGS2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548875-B2 | Inhibitor compounds for male contraception | UNIVERSITY OF WASHINGTON (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | UNIVERSITY OF WASHINGTON (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | ALDH1A1, ALDH3A1, ALDH16A1 | KMT2A 1384/4885MEN1 3040/4885NLRP3 1092/4885 |
| US-11548875-B2 | Inhibitor compounds for male contraception | ALDH1A1, ALDH3A1, ALDH16A1 | KMT2A 1384/4885MEN1 3040/4885NLRP3 1092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.