Sugi Predict

Sugi Predict / Compounds / SCHEMBL2393205

SCHEMBL2393205

SCHEMBL2393205

COC(=O)c1cc(NC(=O)c2cc([N+](=O)[O-])cn2C)cn1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.43
▸ KMT2A Q03164 5/20 0.43
▸ AR P10275 1/20 0.42
▸ P2RY12 Q9H244 1/20 0.41
▸ POLB P06746 2/20 0.40
▸ ALOX5 P09917 2/20 0.40
▸ HPSE Q9Y251 1/20 0.39
▸ HRAS P01112 1/20 0.38
▸ ESR1 P03372 1/20 0.38
▸ TOP1 P11387 1/20 0.38
▸ ESR2 Q92731 1/20 0.38
▸ PRKCA P17252 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ MAPT P10636 3/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ HIF1A Q16665 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20485561 1.00 MEN1 (0.43) MEN1KMT2AARP2RY12POLB
SCHEMBL13224131 1.00 MEN1 (0.43) MEN1KMT2AARP2RY12POLB
SCHEMBL26004721 0.88 HDAC1 (0.42) MEN1KMT2AARP2RY12POLB
SCHEMBL15385157 0.88 HDAC1 (0.42) MEN1KMT2AARP2RY12POLB
SCHEMBL2388875 0.88 MEN1 (0.44) MEN1KMT2AARPOLBALDH1A1
SCHEMBL6180353 0.87 AR (0.44) MEN1KMT2AARP2RY12POLB
SCHEMBL2387448 0.87 AR (0.44) MEN1KMT2AARP2RY12POLB
SCHEMBL10110882 0.87 AR (0.44) MEN1KMT2AARPOLBALOX5
Hydrochloric Acid SCHEMBL27492354 0.86 AR (0.43) MEN1KMT2AARP2RY12POLB
SCHEMBL26004715 0.85 HDAC1 (0.39) MEN1KMT2AARP2RY12POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250313546-A1 NUCLEIC ACID BINDERS UNIVERSITY OF STRATHCLYDE (GB) 2025-10-09 — — US disclosed
EP-4522588-A1 NUCLEIC ACID BINDERS University of Strathclyde (GB) 2025-03-19 — — EP disclosed
CN-119585239-A Nucleic acid binding agents 斯特拉斯克莱德大学 2025-03-07 — — CN disclosed
WO-2023218194-A1 NUCLEIC ACID BINDERS UNIVERSITY OF STRATHCLYDE (GB) 2023-11-16 — — WO disclosed
US-20230310640-A1 PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF LEGOCHEM BIOSCIENCES, INC. (KR) 2023-10-05 — — US disclosed
WO-2023149487-A1 METHOD FOR PRODUCING PYRROLE-IMIDAZOLE POLYAMIDE 国立大学法人千葉大学 2023-08-10 — — WO disclosed
CN-108368006-B DNA binding agents with minor groove binding tails 得克萨斯州大学系统董事会 2023-03-07 — — CN disclosed
US-11505617-B2 Benzodiazepine derivatives IMMUNOGEN, INC. (US) 2022-11-22 — — US disclosed
CN-108727407-B Novel benzodiazepine derivatives 伊缪诺金公司 2022-01-28 — — CN disclosed
US-20210238301-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN, INC. 2021-08-05 — — US disclosed
US-8017599-B2 Sequence selective pyrrole and imidazole polyamide metallocomplexes UNIVERSITY OF WESTERN SYDNEY (AU) 2011-09-13 — — US disclosed
US-20100203007-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN INC. (US) 2010-08-12 — — US disclosed
US-20100203007-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN INC. (US) 2010-08-12 — — US disclosed
US-20100203007-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN INC. (US) 2010-08-12 — — US disclosed
WO-2010091150-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN, INC. (US) 2010-08-12 — — WO disclosed
WO-2010091150-A1 NOVEL BENZODIAZEPINE DERIVATIVES IMMUNOGEN, INC. (US) 2010-08-12 — — WO disclosed
US-7498405-B2 Halogen-substituted thienyl compounds GENESOFT PHARMACEUTICALS, INC. (US) 2009-03-03 — — US disclosed
US-7498405-B2 Halogen-substituted thienyl compounds GENESOFT PHARMACEUTICALS, INC. (US) 2009-03-03 — — US disclosed
US-20070265240-A1 Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes UNIVERSITY OF WESTERN SYDNEY (AU) 2007-11-15 — — US disclosed
WO-2007045096-A1 OLIGOHETEROAROMATIC LUMINISCENT ASSEMBLIES AS HIGH-AFFINITY DNA SEQUENCE-DIRECTED LIGANDS UNIVERSITY OF SASKATCHEWAN (CA) 2007-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238301-A1 NOVEL BENZODIAZEPINE DERIVATIVES GABRB1, GABRB3, GABRA1 MEN1 1702/4885KMT2A 2090/4885AR 805/4885
US-20100203007-A1 NOVEL BENZODIAZEPINE DERIVATIVES GABRB1, GABRB3, GABRA1 MEN1 1702/4885KMT2A 2090/4885AR 805/4885
US-20070265240-A1 Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes POLRMT, MPI, PPIF MEN1 563/4885KMT2A 1205/4885AR 4476/4885
US-11505617-B2 Benzodiazepine derivatives GABBR1, GABRB1, GABRA1 MEN1 1346/4885KMT2A 1831/4885AR 805/4885
US-20250313546-A1 NUCLEIC ACID BINDERS ZFR, NSUN3, POLI MEN1 2882/4885KMT2A 1534/4885AR 1535/4885
US-20230310640-A1 PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF BCR, PDCD1LG2, PRLHR MEN1 2197/4885KMT2A 1221/4885AR 1926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.