SCHEMBL23933307

SCHEMBL23933307

CCOC(=O)C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1(Cl)Cl

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 1/20 0.41
ALDH1A1 P00352 11/20 0.38
MDM2 Q00987 1/20 0.38
KDM4E B2RXH2 1/20 0.38
POLB P06746 3/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 2/20 0.36
CACNA1F O60840 1/20 0.36
CACNA1D Q01668 1/20 0.36
CACNA1S Q13698 1/20 0.36
CACNA1C Q13936 1/20 0.36
HPGD P15428 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 1/20 0.35
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23961574 1.00 GPR35 (0.41) GPR35ALDH1A1MDM2KDM4EPOLB
SCHEMBL23933310 1.00 GPR35 (0.41) GPR35ALDH1A1MDM2KDM4EPOLB
SCHEMBL25870348 0.94 GPR35 (0.39) GPR35ALDH1A1MDM2KDM4EPOLB
SCHEMBL23961570 0.85 GPR35 (0.38) GPR35ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL23933316 0.85 GPR35 (0.38) GPR35ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL23933304 0.85 GPR35 (0.38) GPR35ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL25870323 0.80 MEN1 (0.36) GPR35ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL29493871 0.78 CES2 (0.40) GPR35MEN1KMT2ALMNAMAPT
SCHEMBL18144165 0.78 CES2 (0.40) GPR35ALDH1A1MEN1KMT2ALMNA
SCHEMBL18144169 0.78 CES2 (0.40) GPR35ALDH1A1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115485260-A Processes related to the formation of aryl cyclopropyl carboxylic acids 科迪华农业科技有限责任公司 2022-12-16 CN claimed
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS CORTEVA AGRISCIENCE LLC (US) 2023-07-13 US disclosed
EP-4139272-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS Corteva Agriscience LLC (US) 2023-03-01 EP disclosed
CN-115485260-A Processes related to the formation of aryl cyclopropyl carboxylic acids 科迪华农业科技有限责任公司 2022-12-16 CN disclosed
WO-2021216629-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS CORTEVA AGRISCIENCE LLC (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS DDT, PCCA, DDC GPR35 2605/4885ALDH1A1 72/4885MDM2 2300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.