SCHEMBL23933316

SCHEMBL23933316

COC(=O)[C@H]1[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1(Cl)Cl

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 1/20 0.38
NOTUM Q6P988 1/20 0.37
MAPT P10636 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CES2 O00748 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GUSB P08236 1/20 0.35
GAA P10253 1/20 0.35
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 1/20 0.33
RECQL P46063 1/20 0.33
HTT P42858 1/20 0.33
CFTR P13569 1/20 0.33
P2RX1 P51575 1/20 0.33
TMPRSS4 Q9NRS4 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23961570 1.00 GPR35 (0.38) GPR35NOTUMMAPTMEN1KMT2A
SCHEMBL23933304 1.00 GPR35 (0.38) GPR35NOTUMMAPTMEN1KMT2A
SCHEMBL25870323 0.92 MEN1 (0.36) GPR35NOTUMMAPTMEN1KMT2A
SCHEMBL23961574 0.85 GPR35 (0.41) GPR35MAPTMEN1KMT2AGAA
SCHEMBL23933307 0.85 GPR35 (0.41) GPR35MAPTMEN1KMT2AGAA
SCHEMBL23933310 0.85 GPR35 (0.41) GPR35MAPTMEN1KMT2AGAA
SCHEMBL29493881 0.81 CES2 (0.40) GPR35MAPTMEN1KMT2ACES2
SCHEMBL18144169 0.81 CES2 (0.40) GPR35MAPTMEN1KMT2ACES2
SCHEMBL18144165 0.81 CES2 (0.40) GPR35MAPTMEN1KMT2ACES2
SCHEMBL29493871 0.81 CES2 (0.40) GPR35MAPTMEN1KMT2ACES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4139272-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS Corteva Agriscience LLC (US) 2023-03-01 EP claimed
CN-115485260-A Processes related to the formation of aryl cyclopropyl carboxylic acids 科迪华农业科技有限责任公司 2022-12-16 CN claimed
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS CORTEVA AGRISCIENCE LLC (US) 2023-07-13 US disclosed
EP-4139272-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS Corteva Agriscience LLC (US) 2023-03-01 EP disclosed
CN-115485260-A Processes related to the formation of aryl cyclopropyl carboxylic acids 科迪华农业科技有限责任公司 2022-12-16 CN disclosed
WO-2021216629-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS CORTEVA AGRISCIENCE LLC (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS DDT, PCCA, DDC GPR35 2605/4885NOTUM 177/4885MAPT 4212/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.