Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937904 | 0.71 | LMNA (0.36) | HSD17B10LMNATSHRGAAKDM4E | |
| SCHEMBL20631118 | 0.69 | CA2 (0.32) | HSD17B10LMNATSHRGAAKDM4E | |
| SCHEMBL23937916 | 0.66 | HSD17B10 (0.37) | SMN1; SMN2HSD17B10TSHRMAPTKDM4E | |
| SCHEMBL21957120 | 0.62 | AR (0.41) | MEN1KMT2A | |
| SCHEMBL23937832 | 0.60 | GRM2 (0.32) | — | |
| SCHEMBL19531765 | 0.59 | ALDH1A1 (0.30) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL20756625 | 0.57 | HTR2A (0.62) | HTR2AHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL20631714 | 0.55 | GRM2 (0.32) | — | |
| SCHEMBL14401055 | 0.55 | LMNA (0.55) | SMN1; SMN2LMNATSHRGAAMAPT | |
| SCHEMBL14198837 | 0.54 | HTR2A (0.49) | HTR2AHSD17B10LMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |